Prostate cancer :
Prostate cancer is cancer that starts in the
prostate gland. The prostate is a small, walnut-sized structure that makes up
part of a man's reproductive system. It wraps around the urethra, the tube that
carries urine out of the body. Generally, the tumor usually grows slowly and
remains confined to the gland for many years. During this time, the tumor
produces little or no symptoms or outward signs (abnormalities on physical
examination). However, all prostate cancers do not behave similarly. Some
aggressive types of prostate cancer grow and spread more rapidly than others
and can cause a significant shortening of life expectancy in men affected by
them. The cancer cells may metastasize (spread) from the prostate to other parts of the body,
particularly the bones and lymph
nodes.
Causes, incidence, and risk factors
Prostate cancer is the
most common cause of death from cancer in men over age 75. Prostate cancer is
rarely found in men younger than 40.Rates of
detection of prostate cancers vary widely across the world, with South and East
Asia detecting less frequently than in Europe, and especially the United
States. The estimated lifetime risk of being diagnosed with the disease is
17.6% for Caucasians and 20.6% for African Americans. The lifetime risk of death from
prostate cancer similarly is 2.8% and 4.7% respectively. As reflected in these
numbers, prostate cancer is likely to impact the lives of a significant
proportion of men that are alive today. The risk (predisposing) factors for
prostate cancer include advancing age, genetics (heredity), hormonal
influences, and such environmental factors as toxins, chemicals, and industrial
products. Prostate cancer is more
common among family members of individuals with prostate cancer. This risk may
be two to three times greater than the risk for men without a family history of
the disease.
People who are at higher risk include:
·
African-American
men, who are also likely to develop cancer at every age
·
Men
who are older than 60
·
Men
who have a father or brother with prostate cancer
Other people at risk include:
·
Men
who have been around agent orange
·
Men
who use too much alcohol
·
Farmers
·
Men
who eat a diet high in fat, especially animal fat
·
Tire
plant workers
·
Men
who have been around cadmium
·
There is also a suggestion that obesity leads to an increased risk of having more aggressive,
larger prostate cancer
Prostate cancer is less common in people
who do not eat meat (vegetarians).
A common problem in
almost all men as they grow older is an enlarged prostate. This is called
benign prostatic hyperplasia, or BPH. It does not raise your risk of prostate
cancer. However, it can increase your PSA blood test results.
Symptoms
The PSA blood test is
often done to screen men for prostate cancer. Because of PSA testing, most
prostate cancers are now found before they cause any symptoms.
The symptoms listed below
can occur with prostate cancer, usually at a late stage. These symptoms can
also be caused by other prostate problems:
·
Delayed
or slowed start of urinary
stream
·
flow of urine diminishes
and urination becomes more difficult
·
Dribbling
or leakage of urine, most often after urinating
·
Slow
urinary stream
·
Straining
when urinating, or not being able to empty out all of the urine
·
Blood
in the urine or burning with urination
·
Bone
pain or tenderness, most often in the lower back and pelvic bones (only when
the cancer has spread)
·
As the tumor continues to grow, it can completely block the
flow of urine, resulting in a painfully obstructed and enlarged urinary bladder
Most of these symptoms can occur in men
with non-cancerous (benign) enlargement of the prostate (the most common form
of prostate enlargement). However, the occurrence of these symptoms should
prompt an evaluation by the doctor to rule out cancer and provide appropriate
treatment.
Metastasized Cancer
Furthermore,
in the later stages, prostate cancer can spread locally into the surrounding tissue
or the nearby lymph nodes, called the pelvic nodes. The cancer then can spread
even farther (metastasize) to other areas of the body.
Symptoms:
·
fatigue
·
malaise
Signs
and tests
Screening tests
If a screening test is abnormal, the
disease is then suspected to be present, and further tests usually are needed
to confirm the suspicion (that is, to make the diagnosis definitively).
Prostate cancer usually is suspected initially because of an abnormality of one
or both of the two screening tests that are used to detect prostate cancer.
These screening tests
are
![]() |
| Digital Rectal Exam |
A biopsy is needed to
tell if you have prostate cancer. A sample of tissue is removed from the prostate
and sent to a lab.
Your doctor may recommend a prostate
biopsy if:
·
You
have high PSA level
·
A
rectal exam shows a large prostate or a hard, uneven surface
The results are reported using what is
called a Gleason grade and a Gleason score.
The Gleason grade tells
you how fast the cancer might spread. It grades tumors on a scale of 1 - 5. You
may have different grades of cancer in one biopsy sample. The two main grades
are added together. This gives you the Gleason score. The higher your Gleason
score, the more likely the cancer is to have spread past the prostate:
·
Scores
2 - 5: Low-grade prostate cancer
·
Scores
6 - 7: Intermediate- (or in the middle-) grade cancer. Most prostate cancers
fall into this group.
·
Scores
8 - 10: High-grade cancer
The following tests may be done to
determine whether the cancer has spread:
·
CT scan
The PSA blood test will
also be used to monitor your cancer after treatment. Often, PSA levels will
begin to rise before there are any symptoms. An abnormal digital rectal exam
may be the only sign of prostate cancer (even if the PSA is normal).
Treatment
Treatment depends on many
things, including your Gleason score and your overall health. Your doctor will
discuss your treatment options.
For early-stage prostate cancer, this may
include:
·
Surgery
(radical prostatectomy)
·
Radiation therapy,
including brachytherapy and proton therapy
If you are older, your doctor may
recommend simply monitoring the cancer with PSA tests and biopsies.
If the prostate cancer has spread,
treatment may include:
·
Hormone
therapy (medicines to reduce testosterone levels)
·
Surgery
Surgery, radiation
therapy, and hormone therapy can affect your sexual desire or performance.
Problems with urine control are common after surgery and radiation therapy.
Discuss your concerns with your health care provider.
After treatment for
prostate cancer, you will be closely watched to make sure the cancer does not
spread. This involves routine doctor check-ups, including PSA blood tests
(usually every 3 months to 1 year).


